The Role of RNA Polymerase I Inhibitors in Fungicide Resistance Management

26 February 2025, New Delhi: Introduction to RNA Polymerase I Inhibitors

RNA polymerase I inhibitors are a class of fungicides that target the RNA synthesis machinery within fungal cells. By interfering with this critical process, these inhibitors prevent fungal growth and reproduction, making them effective for managing fungal diseases. However, the challenge of fungicide resistance looms over these powerful chemicals, especially in species like Oomycetes.

The Risk of Resistance and Cross-Resistance

The resistance mechanisms for RNA polymerase I inhibitors remain largely unknown, but they are nonetheless a high-risk category for resistance development. Oomycetes and other fungal pathogens have shown the ability to develop resistance to multiple fungicide classes, which highlights the need for integrated pest management. FRAC guidelines stress the importance of combining fungicides with other management practices to reduce resistance risks.

Implementing Effective Resistance Management

Farmers can extend the life of RNA polymerase I inhibitors by practicing good resistance management. This includes rotating fungicide groups, using non-chemical control methods, and adhering to proper application rates. By following these strategies, the risk of resistance development can be minimized, ensuring that RNA polymerase I inhibitors remain effective in the long run.

Also Read: Low Water, High Risk? Why Drone-Based Pesticide Spraying Raises Concerns

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