New dual mode of action herbicide targets herbicide-resistant weeds in corn, soybean, sunflower and pulse crops
09 July 2026, Washington: FMC Corporation has announced the first global regulatory submission for its novel herbicide active ingredient, rimisoxafen, with the United States Environmental Protection Agency (EPA). The submission covers proposed use of the herbicide in corn, soybean, sunflower and selected pulse crops, marking a significant milestone in the company’s efforts to commercialize next-generation weed management technologies.
According to FMC, rimisoxafen is the first herbicide active ingredient to be classified by the Global Herbicide Resistance Action Committee (HRAC) as a dual mode of action herbicide. The active ingredient has been designated under HRAC Groups 12 and 32, enabling it to inhibit two distinct biochemical pathways in weeds. This dual mechanism is expected to help delay the development of herbicide resistance compared to conventional single mode of action products.
“Filing the first regulatory dossier for rimisoxafen with the EPA represents a significant milestone for FMC,” said Seva Rostovtsev, Executive Vice President and Chief Technology Officer, FMC Corporation. “Years of innovation and scientific discovery have brought us to this point, and we are proud to advance this breakthrough dual mode of action technology through the regulatory process on behalf of growers facing increasingly complex weed resistance challenges.”
The company said rimisoxafen was discovered at FMC’s Stine Research Center following more than a decade of biological research and validation through over 1,000 field and greenhouse studies. The technology has been developed to address the growing challenge of herbicide-resistant weeds, particularly in major row crops.
According to the 2025 National Weed Survey conducted by the Weed Science Society of America, Palmer amaranth and waterhemp remain among the most troublesome broadleaf weeds affecting soybean production in the United States. FMC stated that extensive field evaluations have demonstrated consistent control of both weed species with rimisoxafen.
The United States represents one of the world’s largest herbicide markets, with more than 70 million hectares of corn and soybean cultivated annually and growers spending over US$6 billion each year on weed control. The company believes innovative herbicide technologies with new or underutilized modes of action will play an increasingly important role in sustainable resistance management.
Rimisoxafen is the third novel herbicide active ingredient advanced by FMC to regulatory submission in recent years, following Isoflex™ active and Dodhylex™ active. The company said these submissions reflect the strength of its research and development pipeline and its long-term investment in crop protection innovation.
FMC plans to submit regulatory dossiers for rimisoxafen in additional key agricultural markets as part of its global development programme. The company noted that regulatory approvals will vary by jurisdiction and emphasized that rimisoxafen is not currently registered for sale or use in the United States or any other country. Commercialization will be subject to regulatory review and approval in each market.
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